Due to their anisotropic and specific failure modes, the calculation and design of fiber-reinforced plastics pose a great challenge to the used calculation methods, even in static load cases. This is particularly evident in the use of structure optimization techniques, as the calculation has to reliably differentiate between promising and inferior designs. When optimizing crash or dynamically loaded structures, the calculation becomes even more challenging. Due to the non-linear behavior of these structures in almost all areas, only limited use can be made of classical optimization methods. Instead, experience-based, heuristic methods are a promising alternative as they can handle these strong non-linearities better. In the context of this research project, based on quasistatic and crash tests, a simulation methodology is developed, which is suitable for the heuristic structure optimization of carbon-fiber-reinforced, thermoplastic multi-chamber profiles with the simulation software LS-DYNA. The profiles created in this way are produced using tape laying processes, and their behavior is validated with the simulation.